Normalization procedures and detection of linkage signal in genetical-genomics experiments

Article metrics

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Concordance analysis of linkage statistics based upon three normalization methods.


  1. 1

    Schadt, E.E. et al. Nature 422, 297–302 (2003).

  2. 2

    Yvert, G. et al. Nat. Genet. 35, 57–64 (2003).

  3. 3

    Morley, M. et al. Nature 430, 743–747 (2004).

  4. 4

    Chesler, E.J. et al. Nat. Genet. 37, 233–242 (2005).

  5. 5

    Bystrykh, L. et al. Nat. Genet. 37, 225–232 (2005).

  6. 6

    Hubner, N. et al. Nat. Genet. 37, 243–253 (2005).

  7. 7

    Smyth, G.K. & Speed, T. Methods 31, 265–273 (2003).

  8. 8

    Irizarry, R.A. et al. Nat. Methods 2, 345–350 (2005).

  9. 9

    Cotsapas, C.J. et al. Cold Spring Harb. Symp. Quant. Biol. 68, 109–114 (2003).

Download references


We thank J. Schimenti (formerly of the Jackson Laboratory) and M. Bucan (University of Pennsylvania) for assistance in obtaining mouse strains. Supported by an Australian Research Council Discovery Grant award (P.F.R.L.), a National Health and Medical Research Council Peter Doherty Fellowship (R.B.H.W.), the University of New South Wales Genome Informatics Scholarship (C.J.C.) and Australian Postgraduate Awards (E.C. and M.J.C.) and a grant-in-aid from the Australian Centre for Advanced Computing and Communications (P.F.R.L.).

Author information

Correspondence to Peter F R Little.

Supplementary information

Supplementary Fig. 1

Influence of normalization on genome-wide linkage statistics in ref. 4. (PDF 552 kb)

Supplementary Fig. 2

Influence of transcript variance on concordance analysis of linkage statistics. (PDF 647 kb)

Supplementary Fig. 3

Concordance analysis of linkage 'peaks'. (PDF 782 kb)

Supplementary Table 1

Simulation. (PDF 462 kb)

Supplementary Methods (PDF 83 kb)

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Williams, R., Cotsapas, C., Cowley, M. et al. Normalization procedures and detection of linkage signal in genetical-genomics experiments. Nat Genet 38, 855–856 (2006) doi:10.1038/ng0806-855

Download citation

Further reading