Applied genomics has focused on correlating clinical phenotypes with qualitative differences in DNA sequence such as variations in SNPs. A new study adds a third dimension, allele-specific copy-number differences, combining quantitative and qualitative approaches to understand the relationship between genetic variation and clinical outcome.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Evans, W.E. & McLeod, H.L. N. Engl. J. Med. 348, 538–549 (2003).
Cheng, Q. et al. Nat. Genet. 37, 878–882 (2005).
Tavares, A.S., Costa, J., de Carvalho, A. & Reis, M. Br. J. Cancer 20, 438–441 (1966).
Raimondi, S.C. et al. Cancer 98, 2715–2722 (2003).
Bardi, G., Fenger, C., Johansson, B., Mitelman, F. & Heim, S. J. Clin. Oncol. 22, 2623–2634 (2004).
Kaufman, R.J., Brown, P.C. & Schimke, R.T. Proc. Natl. Acad. Sci. USA 76, 5669–5673 (1979).
Boonsong, A. et al. Cancer Genet. Cytogenet. 121, 56–60 (2000).
McLeod, H.L. & Keith, W.N. Br. J. Cancer 74, 508–512 (1996).
Wang, W., Marsh, S., Cassidy, J. & McLeod, H.L. Cancer Res. 61, 5505–5510 (2001).
Wang, T.L. et al. Proc. Natl. Acad. Sci. USA 101, 3089–3094 (2004).
Cappuzzo, F. et al. J. Natl. Cancer Inst. 97, 643–655 (2005).
Leyland-Jones, B. Lancet Oncol. 3, 137–144 (2002).
Marsh, S., Mallon, M.A., Goodfellow, P. & McLeod, H.L. Proc. Am. Assoc. Cancer Res. 46, 978–979 (2005).
Wojnowski, L. & Brockmoller, J. Pharmacogenetics 14, 267–269 (2004).
Sellers, W.R. & Meyerson, M. J. Natl. Cancer Inst. 97, 326–328 (2005).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
McLeod, H., Marsh, S. Pharmacogenetics goes 3D. Nat Genet 37, 794–795 (2005). https://doi.org/10.1038/ng0805-794
Issue Date:
DOI: https://doi.org/10.1038/ng0805-794
This article is cited by
-
Pharmakogenomik
Monatsschrift Kinderheilkunde (2008)
-
Colorectal cancer pharmacogenomics
Current Colorectal Cancer Reports (2006)