Breaking the bond between an enhancer and a promoter has serious biological consequences. A recent study describes a new chromatin insulator in the Drosophila melanogaster Antennapedia complex (ANTC) that may ensure that nearby enhancers remain faithful to their respective promoters.
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Maeda, R., Karch, F. Ensuring enhancer fidelity. Nat Genet 34, 360–361 (2003). https://doi.org/10.1038/ng0803-360
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DOI: https://doi.org/10.1038/ng0803-360
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