Quantitative modifiers of neoplastic pathways are greatly treasured but difficult to identify at the molecular level. An apparent success has now identified a centrosomal protein kinase that affects many cancer histotypes.
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Aurora kinases are expressed in medullary thyroid carcinoma (MTC) and their inhibition suppresses in vitro growth and tumorigenicity of the MTC derived cell line TT
BMC Cancer Open Access 26 September 2011
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Dove, W. Aurora and the hunt for cancer-modifying genes. Nat Genet 34, 353–354 (2003). https://doi.org/10.1038/ng0803-353
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DOI: https://doi.org/10.1038/ng0803-353
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