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Fungal pathogenicity and morphological switches

The virulence of Candida albicans, a major human fungal pathogen, has been considered dependent on the ability to transition between different morphologies. A new study reports a screen of C. albicans mutants that demonstrates that pathogenesis can be dissociated from morphological switching and in vitro growth rate.

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Figure 1: Various morphological forms of C. albicans.

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Correspondence to P T Magee.

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Magee, P. Fungal pathogenicity and morphological switches. Nat Genet 42, 560–561 (2010). https://doi.org/10.1038/ng0710-560

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