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Hints of hidden heritability in GWAS

Nature Genetics volume 42, pages 558560 (2010) | Download Citation

Although susceptibility loci identified through genome-wide association studies (GWAS) typically explain only a small proportion of the heritability, a classical quantitative genetic analysis now argues that considering together all common SNPs can explain a large proportion of the heritability of these complex traits. A related study provides recommendations for the sample sizes needed in future GWAS to identify additional susceptibility loci.

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Author information

Affiliations

  1. Greg Gibson is in the School of Biology, Georgia Institute of Technology, Atlanta, Georgia, USA.

    • Greg Gibson

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The author declares no competing financial interests.

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Correspondence to Greg Gibson.

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DOI

https://doi.org/10.1038/ng0710-558

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