Although susceptibility loci identified through genome-wide association studies (GWAS) typically explain only a small proportion of the heritability, a classical quantitative genetic analysis now argues that considering together all common SNPs can explain a large proportion of the heritability of these complex traits. A related study provides recommendations for the sample sizes needed in future GWAS to identify additional susceptibility loci.
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Gibson, G. Hints of hidden heritability in GWAS. Nat Genet 42, 558–560 (2010). https://doi.org/10.1038/ng0710-558
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DOI: https://doi.org/10.1038/ng0710-558
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