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Lung stem cells in the balance

Wnt ligands are secreted glycoproteins with critical roles in organogenesis, cancer initiation and progression, and maintenance of stem cell pluripotency. A new study strengthens considerably our understanding of the role of Wnt signaling in progenitor cells of the lung epithelium during development and injury.

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Figure 1: Conserved mechanism of action of β-catenin signaling in the epithelium and mesenchyme during lung development.

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Bellusci, S. Lung stem cells in the balance. Nat Genet 40, 822–823 (2008). https://doi.org/10.1038/ng0708-822

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