The much-anticipated publication of the ENCODE pilot project, representing a detailed and comprehensive characterization of 1% of the human genome, has demonstrated how little we truly understand about how our genes are regulated. Transcripts are nearly everywhere, regulatory sequences remain poorly defined and evolutionary conservation is a surprisingly inadequate predictor of transcriptional features.
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Henikoff, S. ENCODE and our very busy genome. Nat Genet 39, 817–818 (2007). https://doi.org/10.1038/ng0707-817
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DOI: https://doi.org/10.1038/ng0707-817
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