News & Views | Published:

GATA1s goes germline

Acquired somatic mutations in the transcription factor GATA1 are a defining feature of acute megakaryocytic leukemia in children with Down syndrome. A new study shows that similar inherited GATA1 mutations do not promote leukemia in the absence of trisomy 21 but lead to defects in multiple hematopoietic lineages.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Wechsler, J. et al. Nat. Genet. 32, 148–152 (2002).

  2. 2

    Hitzler, J.K., Cheung, J., Li, Y., Scherer, S.W. & Zipursky, A. Blood 101, 4301–4304 (2003).

  3. 3

    Mundschau, G. et al. Blood 101, 4298–4300 (2003).

  4. 4

    Rainis, L. et al. Blood 102, 981–986 (2003).

  5. 5

    Xu, G. et al. Blood 102, 2960–2968 (2003).

  6. 6

    Hollanda, L.M. et al. Nat. Genet. 38, 807–812 (2006).

  7. 7

    Calligaris, R., Bottardi, S., Cogoi, S., Apezteguia, I. & Santoro, C. Proc. Natl. Acad. Sci. USA 92, 11598–11602 (1995).

  8. 8

    Li, Z. et al. Nat. Genet. 37, 613–619 (2005).

  9. 9

    Shimizu, R., Takahashi, S., Ohneda, K., Engel, J.D. & Yamamoto, M. EMBO J. 20, 5250–5260 (2001).

  10. 10

    Shivdasani, R.A., Fujiwara, Y., McDevitt, M.A. & Orkin, S.H. EMBO J. 16, 3965–3973 (1997).

  11. 11

    Kuhl, C. et al. Mol. Cell. Biol. 25, 8592–8606 (2005).

  12. 12

    Muntean, A.G. & Crispino, J.D. Blood 106, 1223–1231 (2005).

  13. 13

    Zipursky, A., Brown, E.J., Christensen, H. & Doyle, J. Clin. Lab. Med. 19, 157–167 (1999).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Further reading

Figure 1: Model of GATA1 function in hematopoiesis and leukemogenesis.

Kim Caesar