The proposal that a distinct subset of colorectal cancers show a marked propensity for promoter CpG island DNA methylation and associated gene silencing has been hotly debated. A new study takes an unbiased approach and not only strongly concludes that a CpG island methylator phenotype exists, but also offers new markers to define a concept that could teach much about the origins of cancer.
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Schuebel, K., Chen, W. & Baylin, S. CIMPle origin for promoter hypermethylation in colorectal cancer?. Nat Genet 38, 738–740 (2006). https://doi.org/10.1038/ng0706-738
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DOI: https://doi.org/10.1038/ng0706-738
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