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A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations

Nature Genetics volume 10, pages 167–174 (1995)Cite this article

Abstract

We have identified a novel gene, Translin, encoding a protein which specifically binds to consensus sequences at breakpoint junctions of chromosomal translocations in many cases of lymphoid malignancies. The encoded protein, Translin, is a previously undescribed type with no significant similarity to known proteins. In the native form, Translin polypeptides form a multimeric structure which is responsible for its DMA binding activity. Nuclear localization of Translin is limited to lymphoid cell lines, raising the intriguing possibility that nuclear transport of Translin is regulated in a physiologically significant way such that active nuclear transport is associated with the lymphoid specific process known as Ig/TCR gene rearrangement.

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Authors and Affiliations

  1. Department of Immunology, National Institute of Health, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162, Japan

    Katsunori Aoki, Takashi Sugano & Masataka Kasai

  2. Department of Pathology, National Institute of Health, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162, Japan

    Kenji Suzuki

  3. Department of Biochemistry and Cell Biology, National Institute of Health, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162, Japan

    Osamu Kuge

  4. The First Department of Internal Medicine, School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, 113, Japan

    Katsunori Aoki

  5. Department of Clinical Pathology, Kyorin University School of Medicine, Mitaka-shi, Tokyo, 181, Japan

    Tetsuya Tasaka & Kazuhiko Nakahara

  6. Mitsubishi-Kasei Institute of Life Sciences, Minami-ooya 11, Machida-shi, Tokyo, 194, Japan

    Akira Omori

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Aoki, K., Suzuki, K., Sugano, T. et al. A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations. Nat Genet 10, 167–174 (1995). https://doi.org/10.1038/ng0695-167

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