Ulcerative colitis and adenocarcinoma of the colon in Gαi2-deficient mice

Nature Genetics volume 10, pages143–150(1995)Cite this article

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Abstract

G proteins are involved in cellular signalling and regulate a variety of biological processes including differentiation and development. We have generated mice deficient for the G protein subunit αi2 (Gαi2) by homologous recombination in embryonic stem cells. Gαi2–deficient mice display growth retardation and develop a lethal diffuse colitis with clinical and histopathological features closely resembling ulcerative colitis in humans, including the development of adenocarcinoma of the colon. Prior to clinical symptoms, the mice show profound alterations in thymocyte maturation and function. The study of these animals should provide important insights into the pathogenesis of ulcerative colitis as well as carcinogenesis.

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Author notes

    • Uwe Rudolph

    Present address: Institute of Pharmacology, University of Zürich, Winterthurerstrasse 190, Zürich, CH-8057, Switzerland

    • Philippe Brabet

    Present address: Centre CNRS-INSERM de Pharmacologie-Endocrinologie, Rue de la Cardonille, 34094, Montpellier, Cedex 2, France

    • Guylain Boulay
    •  & Lutz Birnbaumer

    Present address: Department of Anesthesiology, UCLA School of Medicine, Center for the Health Sciences, 10833 Le Conte Avenue, Los Angeles, California, 90095-1778, USA

Affiliations

  1. Departments of Cell Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, 77030, USA

    • Uwe Rudolph
    • , Yogambal Srinivasan
    • , Philippe Brabet
    • , Guylain Boulay
    •  & Lutz Birnbaumer

  2. Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, 77030, USA

    • Uwe Rudolph

  3. Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, 77030, USA

    • Milton J. Finegold

  4. Department of Microbiology & Immunology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, 77030, USA

    • Susan S. Rich

  5. Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, 77030, USA

    • Gregory R. Harriman
    •  & Lutz Birnbaumer

  6. Department of Molecular Physiology & Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, 77030, USA

    • Lutz Birnbaumer

  7. Department of Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, 77030, USA

    • Lutz Birnbaumer

  8. Department of Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, 77030, USA

    • Allan Bradley

  9. Department of Howard Hughes Medical Institute, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, 77030, USA

    • Allan Bradley

  10. Institute of Pharmacology, University of Zürich, Winterthurerstrasse 190, Zürich, CH-8057, Switzerland

    • Uwe Rudolph

  11. Centre CNRS-INSERM de Pharmacologie-Endocrinologie, Rue de la Cardonille, 34094, Montpellier, Cedex 2, France

    • Philippe Brabet

  12. Department of Anesthesiology, UCLA School of Medicine, Center for the Health Sciences, 10833 Le Conte Avenue, Los Angeles, California, 90095-1778, USA

    • Guylain Boulay
    •  & Lutz Birnbaumer

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Rudolph, U., Finegold, M., Rich, S. et al. Ulcerative colitis and adenocarcinoma of the colon in Gαi2-deficient mice. Nat Genet 10, 143–150 (1995) doi:10.1038/ng0695-143

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