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Prader-Willi and snoRNAs

A new paper reports an individual with the major features of Prader-Willi syndrome (PWS) and a microdeletion in 15q11–q13 removing a cluster of small nucleolar RNAs (snoRNAs). This report provides virtually conclusive evidence that PWS is caused by loss of expression of the C/D box HBII-85 snoRNAs.

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Figure 1: The Prader-Willi domain on chromosome 15q11–13 (not to scale).

Joan Robson


  1. Hall, J. Am. J. Hum. Genet. 46, 857–873 (1990).

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Sahoo, T. et al. Nat. Genet. 40, 719–721 (2008).

    Article  CAS  Google Scholar 

  3. Gunay-Aygun, M. et al. Pediatrics 108, e92 (2001).

    Article  CAS  Google Scholar 

  4. Schüle, B. et al. BMC Med. Genet. 6, 18 (2005).

    Article  Google Scholar 

  5. Burger, J. et al. Am. J. Med. Genet. 111, 233–237 (2002).

    Article  Google Scholar 

  6. Skryabin, B. et al. PLoS Genet. 3, e235 (2007).

    Article  Google Scholar 

  7. Cattanach, B. et al. Nat. Genet. 2, 270–274 (1992).

    Article  CAS  Google Scholar 

  8. Yang, T. et al. Nat. Genet. 19, 25–31 (1998).

    Article  CAS  Google Scholar 

  9. Tsai, T.-F. et al. Hum. Mol. Genet. 8, 1357–1364 (1999).

    Article  CAS  Google Scholar 

  10. Koslov, S. et al. Nat. Genet. 39, 1266–1272 (2007).

    Article  Google Scholar 

  11. Ding, F. et al. PLoS ONE 3, e1709 (2008).

    Article  Google Scholar 

  12. Kiss, T. Cell 109, 145–148 (2002).

    Article  CAS  Google Scholar 

  13. Runte, M. et al. Hum. Genet. 116, 228–230 (2005).

    Article  CAS  Google Scholar 

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Peters, J. Prader-Willi and snoRNAs. Nat Genet 40, 688–689 (2008).

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