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Genome duplication strikes back

Nature Genetics volume 31, pages 128129 (2002) | Download Citation

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The human genome contains up to four paralogs of many Drosophila genes. Two rounds of whole-genome duplication followed by substantial gene loss could explain this pattern easily, but this hypothesis has often been questioned. Mounting evidence from the human genome sequence now confirms at least one genome duplication during early chordate evolution.

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Author information

Affiliations

  1. Institute of Zoology, University of Basel, Biocenter/Pharmacenter, Klingelbergstrasse 50, CH-4056 Basel, Switzerland. j.spring@unibas.ch

    • Jürg Spring

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DOI

https://doi.org/10.1038/ng0602-128

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