Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls


A genetic association between NOTCH4 and schizophrenia has previously been proposed1. Unsing all markers previously shown to be associated, we found no evidence for such in three independent family-based samples (n=519 parent-offspring trios), and a case-control sample derived from the same ethnic background as the original observaton. These data strongly suggest that NOTCH4 is not a significant susceptibility allele for schizophrenia.

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We thank the patients and families for participation and Y.-M. Lim for technical assistance. This study was funded by a research grant from Bristol-Myers Squibb, Millennium Pharmaceuticals and Affymetrix (E.S.L.); the Medical Research Council (UK), the Wellcome Trust, and the Jansen Research Foundation (M.J.O., M.C.O. and G.K.); the German Israeli Foundation for Scientific Research (D.B.W. and B.L.); and Deutsche Forschungsgemeinschaft (SFB400) (W.M. and D.B.W.).

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Correspondence to Pamela Sklar.

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