Abstract
A genetic association between NOTCH4 and schizophrenia has previously been proposed1. Unsing all markers previously shown to be associated, we found no evidence for such in three independent family-based samples (n=519 parent-offspring trios), and a case-control sample derived from the same ethnic background as the original observaton. These data strongly suggest that NOTCH4 is not a significant susceptibility allele for schizophrenia.
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References
Wei J. & Hemmings G.P. Nature Genet. 25, 376–377 (2000).
Editorial. Nature Genet. 22, 1–2 (1999).
Daly, M.J. et al. Am. J. Hum. Genet. 63:A268 (1998).
Terwilliger, J.D. Am. J. Hum. Genet. 56, 777–787 (1995).
Schwab S.G. et al. Nature Genet. 11, 325–327 (1995).
Acknowledgements
We thank the patients and families for participation and Y.-M. Lim for technical assistance. This study was funded by a research grant from Bristol-Myers Squibb, Millennium Pharmaceuticals and Affymetrix (E.S.L.); the Medical Research Council (UK), the Wellcome Trust, and the Jansen Research Foundation (M.J.O., M.C.O. and G.K.); the German Israeli Foundation for Scientific Research (D.B.W. and B.L.); and Deutsche Forschungsgemeinschaft (SFB400) (W.M. and D.B.W.).
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Sklar, P., Schwab, S., Williams, N. et al. Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls. Nat Genet 28, 126–128 (2001). https://doi.org/10.1038/88836
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DOI: https://doi.org/10.1038/88836
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