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Asking the age-old questions

Nature Genetics volume 28, pages 102–104 (2001)Cite this article

Control of lifespan in Caenorhabditis elegans by the DAF-2 insulin-like signaling pathway requires daf-16, which encodes a member of the forkhead family of transcription factors. A new study provides evidence that DAF-2 negatively regulates DAF-16 activity by promoting its retention in the cytoplasm. But, constitutive targeting of DAF-16 to the nucleus is not sufficient to extend lifespan, revealing a new layer of complexity in the genetic control of aging in the nematode.

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References

  1. Lin, K., Hsin, H., Libina, N. & Kenyon, C. Nature Genet. 28, 139–145 (2001).

    Article  CAS  Google Scholar 

  2. Vanfleteren, J.R. & Braeckman, B.P. Neurobiol. Aging 20, 487–502 (1999).

    Article  Google Scholar 

  3. Kimura, K.D., Tissenbaum, H.A., Lui, Y. & Ruvkun, G. Science 277, 942–946 (1997).

    Article  CAS  Google Scholar 

  4. Morris, J.Z., Tissenbaum, H.A. & Ruvkun, G. Nature 382, 536–539 (1996).

    Article  CAS  Google Scholar 

  5. Ogg, S. & Ruvkun, G. Mol. Cell 2, 887–893 (1998).

    Article  CAS  Google Scholar 

  6. Paradis, S. & Ruvkun, G. Genes Dev. 12, 2488–2498 (1998).

    Article  CAS  Google Scholar 

  7. Paradis, S., Ailion, M., Toker, A., Thomas, J.H. & Ruvkun, G. Genes Dev. 13, 1438–1452 (1999).

    Article  CAS  Google Scholar 

  8. Ogg, S. et al. Nature 389, 994–999 (1997).

    Article  CAS  Google Scholar 

  9. Lin, K., Dorman, J.B., Rodan, A. & Kenyon, C. Science 278, 1319–1322 (1997).

    Article  CAS  Google Scholar 

  10. Riddle, D.L. & Albert, P.S. in C. elegans II (eds. Riddle, D.L., Blumenthal, T., Meyer, B.J., & Priess, J.R.) 739–768 (Cold Spring Harbor Laboratory Press, Cold Spring Harbor 1997).

    Google Scholar 

  11. Guarente, L. & Kenyon, C. Nature 408, 255–262 (2000).

    Article  CAS  Google Scholar 

  12. McGhee, J.D. & Krause, M.W. in C. elegans II (eds Riddle, D.L., Blumenthal, T., Meyer, B.J. & Priess, J.R.) 147–184 (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, 1997).

    Google Scholar 

  13. Clancy, D.J. et al. Science 292, 104–106 (2001).

    Article  CAS  Google Scholar 

  14. Tatar, M. et al. Science 292, 107–110 (2001).

    Article  CAS  Google Scholar 

Download references

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  1. Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California, USA

    Pamela L Larsen

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  1. Pamela L Larsen
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Larsen, P. Asking the age-old questions. Nat Genet 28, 102–104 (2001). https://doi.org/10.1038/88797

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