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Robustness—it's not where you think it is

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A new study indicates that closely related genes in yeast may be less redundant than expected. Instead, the stability of genetic networks—which buffers the deleterious effect of mutations—may be due to the actions of unrelated genes.

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References

  1. 1

    Wagner, A. Nature Genet. 24, 355–361 (2000).

  2. 2

    Smith, V., Chou, K.N., Lashkari, D., Botstein, D. & Brown, P.O. Science 274, 2069– 2074 (1996).

  3. 3

    Winzeler, E.A. et al. Science 285, 901–906 (1999).

  4. 4

    Mortimer, R.K. Genetics 61, 329–334 ( 1969).

  5. 5

    Dujon, B. Trends Genet. 12, 263–270 (1996).

  6. 6

    Delneri, D., Gardner, D.C. & Oliver, S.G. Genetics 153, 1591– 1600 (1999).

  7. 7

    Seoighe, C. & Wolfe, K.H. Curr. Opin. Microbiol. 2, 548–554 (1999).

  8. 8

    Ohno, S. Evolution by Gene Duplication (George Allen and Unwin, London, 1970).

  9. 9

    Kimura, M. & Ohta, T. Proc. Natl Acad. Sci. USA 71, 2848–2852 (1974).

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