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Integrated human genome–wide maps constructed using the CEPH reference panel

Nature Genetics volume 6, pages 391–393 (1994)Cite this article

Abstract

High resolution linkage maps have proven to be invaluable tools in genetic investigations. We have assembled a collection of genetic maps constructed from primary data collected from investigators performing genotyping using the Centre Etude Polymorphism Humain (CEPH) reference pedigree panel. These maps were constructed using a rigorous, semi–automated map construction algorithm that evaluates the integrity of the maps during construction. Two classes of maps were produced: a high confidence “skeletal” set composed of 544 PCR based markers, and a more highly annotated “framework” set containing maps of 1,123 markers. Genetic map locations within the framework maps are provided for an additional 1,758 loci without statistically unique interval assignments.

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Authors and Affiliations

  1. Division of Population Science, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, Pennsylvania, 19111, USA

    Kenneth H. Buetow, Susan Ludwigsen & Titia Scherpbier-Heddema

  2. Center for Medical Genetics, Marshfield Medical Research Foundation, Marshfield, Wisconsin, 54449, USA

    James L. Weber & Zhenyuan Wang

  3. Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School Boston, Massachusetts, 02115, USA

    Geoffrey M. Duyk

  4. Department of Pediatrics, The University of Iowa, Iowa City, Iowa, 52242, USA

    Val C. Sheffield & Jeffrey C. Murray

Authors
  1. Kenneth H. Buetow
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  2. James L. Weber
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  3. Susan Ludwigsen
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  4. Titia Scherpbier-Heddema
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  5. Geoffrey M. Duyk
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  6. Val C. Sheffield
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  7. Zhenyuan Wang
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  8. Jeffrey C. Murray
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Buetow, K., Weber, J., Ludwigsen, S. et al. Integrated human genome–wide maps constructed using the CEPH reference panel. Nat Genet 6, 391–393 (1994). https://doi.org/10.1038/ng0494-391

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  • DOI: https://doi.org/10.1038/ng0494-391

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