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Stopping RNA interference at the seed

MicroRNAs (miRNAs) regulate expression of more than one half of the genes in the human genome. A study now reports a new method for selectively silencing whole families of miRNAs, thus providing a new paradigm for disease therapy.

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Figure 1: Silencing miRNA families with tiny LNAs.


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Correspondence to John J Rossi.

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The author declares no competing financial interests.

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Rossi, J. Stopping RNA interference at the seed. Nat Genet 43, 288–289 (2011).

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