HIV-1 positive feedback and lytic fate

The HIV viral lifecycle includes infection of a host cell, followed by a critical decision between latency and lysis. A new study suggests that positive feedback in the HIV-1 promoter, involving Tat protein and gene expression, has a role in this critical choice of fate.

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Figure 1: Relationship between feedback strength, Tat expression transients and fate decisions.


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Nachman, I., Ramanathan, S. HIV-1 positive feedback and lytic fate. Nat Genet 40, 382–383 (2008).

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