A new study uses an evolutionary approach to characterize the diversity within populations of cells in Barrett's esophagus lesions. Greater genetic clonal diversity is found to be associated with higher risks for transformation.
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References
Hahn, W.C. & Weinberg, R.A. N. Engl. J. Med. 347, 1593–1603 (2002).
Nowell, P.C. Science 194, 23–28 (1976).
Maley, C.C. et al. Nat. Genet. 38, 468–473 (2006).
Gould, S.J. & Eldredge, N. Nature 366, 223–227 (1993).
Paulson, T.G. & Reid, B.J. Cancer Cell 6, 11–16 (2004).
Barrett, M.T. et al. Nat. Genet. 22, 106–109 (1999).
Tomlinson, I. & Bodmer, W. Nat. Med. 5, 11–12 (1999).
Calabrese, P., Tavaré, S. & Shibata, D. Am. J. Pathol. 164, 1337–1346 (2004).
Vogelstein, B. & Kinzler, K.W. Proc. Natl. Acad. Sci. USA 96, 9236–9241 (1999).
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Shibata, D. Clonal diversity in tumor progression. Nat Genet 38, 402–403 (2006). https://doi.org/10.1038/ng0406-402
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DOI: https://doi.org/10.1038/ng0406-402
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