Sirtuins for healthy neurons

Sir2 deacetylases are believed to promote the survival and longevity of organisms during times of adversity. A new study shows that activation of Sir2 by small molecules called sirtuin-activating compounds increases neuronal survival in two different models of Huntington disease, possibly opening new avenues for treatment.

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Figure 1: Routes to increasing the activity of sirtuin deacetylases.

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Sinclair, D. Sirtuins for healthy neurons. Nat Genet 37, 339–340 (2005) doi:10.1038/ng0405-339

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