A twist on admixture mapping

A new study uses genome-wide SNP genotypes to identify a subset of children undergoing therapy for acute lymphoblastic leukemia that are at increased risk for relapse. Borrowing from the classical approach of admixture mapping, the work shows how genome-wide assessment of genetic ancestry can be used as a biomarker for disease outcome.

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Figure 1: Principal component analysis of genome-wide SNP genotyping data can distinguish an admixed population from other populations.


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Correspondence to Stephen J Chanock.

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Chanock, S. A twist on admixture mapping. Nat Genet 43, 178–179 (2011). https://doi.org/10.1038/ng0311-178

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