New insights into oncogenic stress

Expression of oncogenes in otherwise normal cells often leads to the activation of anti-oncogenic pathways through a poorly understood process described as 'oncogenic stress'. A new study implicates the Jnk pathway signaling in the activation of p53 in response to both K-Ras and Neu oncogene expression.

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Figure 1: Pathways leading to cell cycle arrest due to oncogenic stress.

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Correspondence to Kevin M Haigis or Alejandro Sweet-Cordero.

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Haigis, K., Sweet-Cordero, A. New insights into oncogenic stress. Nat Genet 43, 177–178 (2011). https://doi.org/10.1038/ng0311-177

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