A new study has identified a large number of open chromatin regions harboring active regulatory elements in human pancreatic islets. A type 2 diabetes–associated SNP in TCF7L2 was found to be located in a region of allele-specific open chromatin and shows allele-specific enhancer activity, suggesting a potential mechanism for this disease association.
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The involvement of the wnt signaling pathway and TCF7L2 in diabetes mellitus: The current understanding, dispute, and perspective
Cell & Bioscience Open Access 14 August 2012
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The author declares no competing financial interests.
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Groop, L. Open chromatin and diabetes risk. Nat Genet 42, 190–192 (2010). https://doi.org/10.1038/ng0310-190