In the nematode Caenorhabditis elegans, dosage compensation is mediated by a subtle twofold downregulation of both X chromosomes. A new study provides a significant advance in our understanding of how the X is targeted for dosage compensation and how this global regulation is integrated with regulation of the expression of each gene.
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Reinke, V. Think globally, act locally. Nat Genet 39, 287–289 (2007). https://doi.org/10.1038/ng0307-287
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DOI: https://doi.org/10.1038/ng0307-287