Hedgehogs on the road to polarity

Mutations in components of the planar cell polarity pathway in mammals give rise to neural tube defects, anomalous cochlear hair cell stereocilia and kidney cysts. A new study suggests that two planar cell polarity components initially characterized in flies are required for ciliogenesis and Hedgehog signaling in frog embryos, providing insights into the mechanisms governing positioning and growth of the ciliary axoneme.

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Figure 1: Model linking the PCP effector proteins Inturned and Fuzzy to the noncanonical Wnt pathway and Hh signaling in vertebrates.

Katie Ris

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Beales, P. Hedgehogs on the road to polarity. Nat Genet 38, 277–279 (2006). https://doi.org/10.1038/ng0306-277

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