Marking time

Special chromosome marks are thought to maintain the stable pattern of gene expression that underlies cell identity. Surprisingly, similar chromosome marks accompany cyclic gene expression driven by the 24-hour circadian clock.

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Figure 1: Circadian regulation of target genes is regulated by CLOCK-BMAL1 complex binding and chromatin modification.

Katie Ris

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Eissenberg, J., Elgin, S. Marking time. Nat Genet 38, 276–277 (2006). https://doi.org/10.1038/ng0306-276

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