The mechanism by which cytosine methylation stably represses transcription is of great interest. A new study provides evidence associating DNA methylation, MeCP2 and the SWI/SNF chromatin-remodeling factor, implicating local chromatin architecture in DNA methylation–dependent transcriptional repression.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Bestor, T.H. Hum. Mol. Genet. 9, 2395–2402 (2000).
N, H.K. et al. Nat. Genet. 37, 254–264 (2005).
Ohki, I. et al. Cell 105, 487–497 (2001).
Jones, P.L. et al. Nat. Genet. 19, 187–191 (1998).
Nan, X. et al. Nature 393, 386–389 (1998).
Narlikar, G.F., Fan, H.Y. & Kingston, R.E. Cell 108, 475–487 (2002).
Bird, A. & Wolffe, A.P. Cell 99, 451–454 (1999).
Chandler, S.P., Guschin, D., Landsberger, N. & Wolffe, A.P. Biochemistry 38, 7008–7018 (1999).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wade, P. SWItching off methylated DNA. Nat Genet 37, 212–213 (2005). https://doi.org/10.1038/ng0305-212
Issue Date:
DOI: https://doi.org/10.1038/ng0305-212
This article is cited by
-
Ovine HSP90AA1 gene promoter: functional study and epigenetic modifications
Cell Stress and Chaperones (2015)
