Intoxicated cells and stomach ulcers

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Helicobacter pylori induces chronic gastritis in virtually all hosts, yet only a fraction of colonized patients ever develop peptic ulcer disease. A new study shows that binding of the H. pylori virulence determinant VacA by a receptor tyrosine phosphatase, Ptprz, modifies the phosphorylation pattern of gastric epithelial cell proteins and leads to cellular detachment. As activation of Ptprz also results in gastric injury and ulceration in vivo, these findings help explain why VacA-expressing strains of H. pylori augment the risk for peptic ulcer disease

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References

  1. 1

    Marshall, B.J. & Warren, J.R. Lancet 1, 1311–1315 (1984).

  2. 2

    Peek, R.M. Jr. & Blaser, M.J. Nat. Rev. Cancer 2, 28–37 (2002).

  3. 3

    Fujikawa, A. et al. Nat. Genet. 33, 375–381 (2003).

  4. 4

    Cover, T.L., Tummuru, M.K., Cao, P., Thompson, S.A. & Blaser, M.J. J. Biol. Chem. 269, 10566–10573 (1994).

  5. 5

    Atherton, J.C. et al. J. Biol. Chem 270, 17771–17777 (1995).

  6. 6

    Lupetti, P. et al. J. Cell Biol 133, 801–807 (1996).

  7. 7

    Cover, T.L., Hanson, P.I. & Heuser, J.E. J. Cell Biol. 138, 759–769 (1997).

  8. 8

    Szabo, I. et al. EMBO J. 18, 5517–5527 (1999).

  9. 9

    McClain, M.S., Schraw, W., Ricci, V., Boquet, P. & Cover, T.L. Mol. Microbiol. 37, 433–442 (2000).

  10. 10

    Telford, J.L. et al. J. Exp. Med. 179, 1653–1658 (1994).

  11. 11

    Ghiara, P. et al. Infect. Immun. 63, 4154–4160 (1995).

  12. 12

    Peek, R.M. Jr. et al. Cancer Res. 59, 6124–6131 (1999).

  13. 13

    Tombola, F. et al. J. Clin. Invest. 108, 929–937 (2001).

  14. 14

    Papini, E. et al. J. Clin. Invest. 102, 813–820 (1998).

  15. 15

    Padilla, P.I. et al. J. Biol. Chem. 275, 15200–15206 (2000).

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Peek, R. Intoxicated cells and stomach ulcers. Nat Genet 33, 328–330 (2003) doi:10.1038/ng0303-328

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