When DNA-binding proteins are tethered to dam methylase from Escherichia coli, adenine methylation is directed to eukaryotic target sites in vivo. Hybridization of methylated DNA to microarrays allows binding sites to be displayed genome-wide, providing a versatile alternative to chromatin immunoprecipitation.
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Martienssen, R. Chipping away at chromatin. Nat Genet 27, 240–241 (2001). https://doi.org/10.1038/85787
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DOI: https://doi.org/10.1038/85787
