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Variation is the spice of life

Assembling a comprehensive catalog of common human sequence polymorphisms is a key goal of the Human Genome Project. The International SNP Map Working Group has compiled a map of 1.4 million single-nucleotide polymorphisms. What fraction of all human sequence variation is captured in this collection, and what further advances are needed before the map becomes a useful tool for genetic studies?

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Kruglyak, L., Nickerson, D. Variation is the spice of life. Nat Genet 27, 234–236 (2001). https://doi.org/10.1038/85776

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