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A major susceptibility locus to murine lung carcinogenesis maps on chromosome 6

Nature Genetics volume 3, pages 132–136 (1993)Cite this article

Abstract

Lung tumours represent a major cause of death in humans, and although smoking represents the main pathogenetic factor, inheritance also plays a part. However, the identification of possible predisposing genetic factors is difficult, because of their low penetrance. We took advantage of murine strains that are genetically susceptible or resistant to lung tumour development, to map murine genes associated with susceptibility to lung carcinogenesis. An F2 population of urethan–treated A/J × C3H/He mice was scored with 83 genetic markers. A chromosome 6 distal region, spanning 35 centiMorgans, contained a major lung tumour susceptibility locus. No other chromosomal region was significantly associated with lung tumour development.

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Authors and Affiliations

  1. Division of Experimental Oncology A, Istituto Nazionale Tumori, University of Milan, Milan, Italy

    Manuela Gariboldi, Giacomo Manenti, Federico Canzian, F. Stefania Falvella, M. Teresa Radice, Marco A. Pierotti, Giuseppe Della Porta & Tommaso A. Dragani

  2. Department of Genetics and Microbiology, University of Milan, Milan, Italy

    Giorgio Binelli

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  1. Manuela Gariboldi
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  2. Giacomo Manenti
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  3. Federico Canzian
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  4. F. Stefania Falvella
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  9. Tommaso A. Dragani
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Gariboldi, M., Manenti, G., Canzian, F. et al. A major susceptibility locus to murine lung carcinogenesis maps on chromosome 6. Nat Genet 3, 132–136 (1993). https://doi.org/10.1038/ng0293-132

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