Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Hair lost in translation

Nature Genetics volume 41, pages 141–142 (2009)Cite this article

A new study identifies mutations in the HR gene as the cause of Marie Unna hereditary hypotrichosis (MUHH). The mutations seem to disrupt an unusual leader sequence–based mechanism of translational repression, making MUHH the first example of a disease linked to this form of repression.

Focus on the upstream ORFs

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

Buy

All prices are NET prices.

Figure 1: Hair loss phenotypes in man and mouse.

References

  1. Panteleyev, A.A., Paus, R., Ahmad, W., Sundberg, J.P. & Christiano, A.M. Exp. Dermatol. 7, 249–267 (1998).

    Article  CAS  PubMed  Google Scholar 

  2. Ahmad, W. et al. Science 279, 720–724 (1998).

    Article  CAS  PubMed  Google Scholar 

  3. Cichon, S. et al. Hum. Mol. Genet. 7, 1671–1679 (1998).

    Article  CAS  PubMed  Google Scholar 

  4. Cachon-Gonzalez, M.B. et al. Proc. Natl. Acad. Sci. USA 91, 7717–7721 (1994).

    Article  CAS  PubMed  Google Scholar 

  5. Ahmad, W., Panteleyev, A.A., Sundberg, J.P. & Christiano, A.M. Genomics 53, 383–386 (1998).

    Article  CAS  PubMed  Google Scholar 

  6. Wen, Y. et al. Nat. Genet. 41, 228–233 (2009).

    Article  CAS  PubMed  Google Scholar 

  7. Stelzner, K.F. J. Hered. 74, 193–196 (1983).

    Article  CAS  PubMed  Google Scholar 

  8. Liu, Y. et al. J. Invest. Dermatol. 127, 1605–1614 (2007).

    Article  CAS  PubMed  Google Scholar 

  9. Montagna, W., Chase, H.B. & Melaragno, H.P. J. Invest. Dermatol. 19, 83–94 (1952).

    Article  CAS  PubMed  Google Scholar 

  10. Panteleyev, A.A., Botchkareva, N.V., Sundberg, J.P., Christiano, A.M. & Paus, R. Am. J. Pathol. 155, 159–171 (1999).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Beaudoin, G.M. III, Sisk, J.M., Coulombe, P.A. & Thompson, C.C. Proc. Natl. Acad. Sci. USA 102, 14653–14658 (2005).

    Article  CAS  PubMed  Google Scholar 

  12. Zarach, J.M., Beaudoin, G.M.J., III, Coulombe, P.A. & Thompson, C.C. Development 131, 4189–4200 (2004).

    Article  CAS  PubMed  Google Scholar 

  13. Soler, A.P., Gilliard, G., Megosh, L.C. & O'Brien, T.G. J. Invest. Dermatol. 106, 1108–1113 (1996).

    Article  CAS  PubMed  Google Scholar 

  14. Law, G.L., Raney, A., Heusner, C. & Morris, D.R. J. Biol. Chem. 276, 38036–38043 (2001).

    CAS  PubMed  Google Scholar 

  15. Raney, A., Law, G.L., Mize, G.J. & Morris, D.R. J. Biol. Chem. 277, 5988–5994 (2002).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Lorin Weiner and Janice L. Brissette are at the Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA. lorin.weiner@cbrc2.mgh.harvard.edu janice.brissette@cbrc2.mgh.harvard.edu,

    Lorin Weiner & Janice L Brissette

Authors
  1. Lorin Weiner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Janice L Brissette
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Weiner, L., Brissette, J. Hair lost in translation. Nat Genet 41, 141–142 (2009). https://doi.org/10.1038/ng0209-141

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng0209-141

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing