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Conquering the male germ line

Nature Geneticsvolume 30pages133134 (2002) | Download Citation

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In 1994, Ralph Brinster and colleagues demonstrated that male germ cells could repopulate a mouse testis into which they had been transplanted and could then continue and complete their differentiation. They now report production of transgenic progeny after retroviral infection of germline stem cells in culture prior to their transfer to a recipient male. This achievement may lead to new developments in the manipulation and study of mammalian genomes.

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Author information

Affiliations

  1. U470, INSERM, Centre de Biochimie, Universite de Nice, Parc Valrose, 06108, Nice, France

    • Minoo Rassoulzadegan

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https://doi.org/10.1038/ng0202-133

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