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Interleukin 12 and autoimmune diabetes

Nature Genetics volume 27, pages 131–132 (2001)Cite this article

Interleukin 12 (IL-12) has been implicated in the pathogenesis of type 1 diabetes in the non-obese diabetic (NOD) mouse. Following this lead, a new locus associated with human type 1 diabetes, IDDM18, has been identified near the gene encoding the p40 subunit of interleukin 12 (IL12B). This finding has potential implications for the prediction of at-risk individuals and, perhaps, for the implementation of prevention strategies relevant to several autoimmune diseases.

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References

  1. Mein, C.A. et al. Nature Genet. 19, 297–300 (1998).

    Article  CAS  Google Scholar 

  2. Morahan, G. Nature Genet. 27, 218–221 (2001).

    Article  CAS  Google Scholar 

  3. Gately, M.K. et al. Annu. Rev. Immunol. 16, 495–512 (1998).

    Article  CAS  Google Scholar 

  4. Trinchieri, G. Annu. Rev. Immunol. 13, 251–276 (1995).

    Article  CAS  Google Scholar 

  5. Atkinson, M.A. & Leiter, E.H. Naure Med. 5, 601–604 (1999).

    CAS  Google Scholar 

  6. Trembleau, S. et al. J. Exp. Med. 181, 817–821 (1995).

    Article  CAS  Google Scholar 

  7. Trembleau, S. et al. J. Immunol. 165, 6748–6755 (2000).

    Article  CAS  Google Scholar 

  8. Trembleau, S., Penna, G., Gregori, S., Gately, M.K. & Adorini, L. Eur. J. Immunol. 27, 2230–2239 (1997).

    Article  Google Scholar 

  9. Rothe, H., O'Hara, R.M., Martin, S. & Kolb, H. Diabetologia 40, 641–646 (1997).

    Article  CAS  Google Scholar 

  10. Trembleau, S. et al. J. Immunol. 163, 2960–2968 (1999).

    CAS  PubMed  Google Scholar 

  11. Hultgren, B., Huang, X., Dybdal, N. & Stewart, T.A. Diabetes 45, 812–817 (1996).

    Article  CAS  Google Scholar 

  12. Benoist, C. & Mathis, D. Cell 89, 1–3 (1997).

    Article  CAS  Google Scholar 

  13. Szelachowska, M., Kretowski, A. & Kinalska, I. Horm. Metab. Res. 29, 168–171 (1997).

    Article  CAS  Google Scholar 

  14. Adorini, L. et al. Chem. Immunol. 68, 175–197 (1997).

    Article  CAS  Google Scholar 

  15. Oppmann, B. et al. Immunity 13, 715–725 (2000).

    Article  CAS  Google Scholar 

Download references

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  1. Roche Milano Ricerche, Milano, 20132, Italy

    Luciano Adorini

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  1. Luciano Adorini
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Adorini, L. Interleukin 12 and autoimmune diabetes. Nat Genet 27, 131–132 (2001). https://doi.org/10.1038/84732

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