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Diminished support for linkage between manic depressive illness and X–chromosome markers in three Israeli pedigrees

Nature Genetics volume 3, pages 49–55 (1993)Cite this article

Abstract

The hypothesis that chromosomal region Xq27–28 harbours a gene for manicdepression has been a focus of interest in human genetics. X–linked inheritance of manic depressive illness has been re–examined in 3 multigeneration Israeli kindreds. Extension and re–evaluation of pedigree data, including new individuals, diagnostic follow–up, and analysis with DMA markers, shows greatly diminished support for linkage to Xq28. The peak lod scores in two of the pedigrees have dropped several lod units to clearly negative values at the RCP–F8–G6PD gene cluster. On the other hand, positive lod scores (Zmax = 2.09) are sustained in another pedigree at the same map location. None of the pedigrees show linkage to more proximal markers, including the Xq27 locus DXS98. Our analysis underscores the uncertainties in studying complex disorders.

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Author notes

  1. Nelson F. Freimer & Amy Peterson

    Present address: Langley Porter Psychiatric Institute and Department of Psychiatry, University of California at San Francisco, San Francisco, California, 94143, USA

Authors and Affiliations

  1. New York State Psychiatric Institute and Departments of Psychiatry and Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York, 10032, USA

    Miron Baron, Nelson F. Freimer, Richard E. Straub, Susha Asokan, Kamna Das, Amy Peterson, Jean Endicott, Jurg Ott & T. Conrad Gilliam

  2. Departments of Epidemiology and Public Health and of Genetics, Yale University School of Medicine, New Haven, Connecticut, 06510, USA

    Neil Risch

  3. Department of Psychiatry, Hadassah–Hebrew University Medical Center, Jerusalem, 91120, Israel

    Bernard Lerer & Joyce R. Alexander

  4. Center for Human Genetics, Boston University Medical Center, Boston, Massachusetts, 02118, USA

    Jean Amos

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Baron, M., Freimer, N., Risch, N. et al. Diminished support for linkage between manic depressive illness and X–chromosome markers in three Israeli pedigrees. Nat Genet 3, 49–55 (1993). https://doi.org/10.1038/ng0193-49

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