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Basal bodies, kinocilia and planar cell polarity

Primary cilia and planar cell polarity (PCP) proteins both contribute to cell polarization, but their relationship is unclear. A new study shows that, in the organ of Corti, primary cilia are required for morphological polarization of sensory hair cells and function downstream of the PCP signaling proteins.

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Figure 1: PCP and kinocilia in the organ of Corti.

Katie Vicari

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Axelrod, J. Basal bodies, kinocilia and planar cell polarity. Nat Genet 40, 10–11 (2008). https://doi.org/10.1038/ng0108-10

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