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Sending out an SOS

Nature Genetics volume 39, pages 89 (2007) | Download Citation

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Noonan syndrome is a disease caused by aberrant signaling through the Ras GTPase, yet the underlying causal mutations remain unknown in many affected individuals. Two papers now identify gain-of-function mutations in the Ras nucleotide exchange factor SOS1 as a new player in this common developmental disorder.

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Author information

Affiliations

  1. Kevin Shannon is in the Department of Pediatrics and Comprehensive Cancer Center, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, California 94143, USA.

    • Kevin Shannon
    •  & Gideon Bollag
  2. Gideon Bollag is at Plexxikon, Inc., 91 Bolivar Drive, Berkeley, California 94710, USA. shannonk@peds.ucsf.edu.

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DOI

https://doi.org/10.1038/ng0107-8

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