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Cross-species comparisons of cancer signaling

Modeling of human cancer in genetically engineered mice and genome-wide measurements of mRNA expression have now been combined to accelerate the search for new molecularly targeted therapies against cancer. Looking forward, we propose a community-wide systematic effort to model and characterize an array of different cancer-related aberrant signaling pathways in several mouse models of cancer.

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Figure 1: Using mouse models to explore systematically the gene-expression changes associated with aberrant cancer signaling pathways across different tissue types.


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Graeber, T., Sawyers, C. Cross-species comparisons of cancer signaling. Nat Genet 37, 7–8 (2005).

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