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Cross-species comparisons of cancer signaling

Nature Genetics volume 37, pages 7–8 (2005)Cite this article

Modeling of human cancer in genetically engineered mice and genome-wide measurements of mRNA expression have now been combined to accelerate the search for new molecularly targeted therapies against cancer. Looking forward, we propose a community-wide systematic effort to model and characterize an array of different cancer-related aberrant signaling pathways in several mouse models of cancer.

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Figure 1: Using mouse models to explore systematically the gene-expression changes associated with aberrant cancer signaling pathways across different tissue types.

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Authors and Affiliations

  1. Crump Institute for Molecular Imaging and the Department of Molecular and Medical Pharmacology,

    Thomas G Graeber & Charles L Sawyers

  2. Howard Hughes Medical Institute, and the Departments of Medicine, Molecular and Medical Pharmacology, and Urology at the David Geffen School of Medicine, University of California, Los Angeles, 90095, California, USA

    Thomas G Graeber & Charles L Sawyers

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  1. Thomas G Graeber
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  2. Charles L Sawyers
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Graeber, T., Sawyers, C. Cross-species comparisons of cancer signaling. Nat Genet 37, 7–8 (2005). https://doi.org/10.1038/ng0105-7

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