Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Learning from lentiviruses

Nature Genetics volume 24, pages 8–9 (2000)Cite this article

Abstract

The advantage that vectors derived from the human immunodeficiency virus offer over other gene-delivery vehicles is their ability to transduce non-proliferative tissues. But a report by Park et al. suggests that HIV-based vectors are not able to infect all non-dividing cells and that host cell activation may influence efficiency of gene delivery.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Amado, R.G. & Chen, I.S., Science 285, 674–676 (1999).

    Article  CAS  PubMed  Google Scholar 

  2. Park, F., Ohashi, K., Chiu, W., Naldini, L. & Kay, M.A., Nature Genet. 24, 49– 52 (2000).

    Article  CAS  PubMed  Google Scholar 

  3. Lewis, P.F. & Emerman, M., J. Virol. 68, 510–516 (1994).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Fouchier, R.A. & Malim, M.H., Adv. Virus Res. 52, 275–299 (1999).

    Article  CAS  PubMed  Google Scholar 

  5. Tang, S., Patterson, B. & Levy, J.A., J. Virol. 69, 5659– 5665 (1995).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Korin, Y.D. & Zack, J.A., J. Virol. 73, 6526–6532 (1999).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Korin, Y.D. & Zack, J.A., J. Virol. 72, 3161–3168 (1998).

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Kinoshita, S., Chen, B.K., Kaneshima, H. & Nolan, G.P., Cell 95, 595–604 ( 1998).

    Article  CAS  PubMed  Google Scholar 

  9. Unutmaz, D., Kewal Ramani, V.N., Marmon, S. & Littman, D.R., J. Exp. Med. 189, 1735–1746 (1999).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Zhang, Z.Q., et al. Science 286, 1353– 1357 (1999).

    Article  CAS  PubMed  Google Scholar 

  11. Meyerson, M. & Harlow, E., Mol. Cell. Biol. 14, 2077–2086 (1994).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Perelson, A.S., Neumann, A.U., Markowitz, M., Leonard, J.M. & Ho, D.D., Science 271, 1582–1585 (1996).

    Article  CAS  PubMed  Google Scholar 

  13. Klein, N.P., Bouchard, M.J., Wang, L.H., Kobarg, C. & Schneider, R.J., EMBO J. 18, 5019–5027 (1999).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Yamada, Y., Kirillova, I., Peschon, J.J. & Fausto, N., Proc. Natl Acad. Sci. USA 94, 1441– 1446 (1997).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, 98109-1024, Washington, USA

    Michael Emerman

Authors
  1. Michael Emerman
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Emerman, M. Learning from lentiviruses. Nat Genet 24, 8–9 (2000). https://doi.org/10.1038/71740

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/71740

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing