Two new studies describe germline mutations in BAP1 in putatively dissimilar cancer-related syndromes. The spectrum of neoplasms associated with these germline mutations suggest that BAP1 has an important tumor suppressor function in multiple tissues.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Deficiency of BAP1 inhibits neuroblastoma tumorigenesis through destabilization of MYCN
Cell Death & Disease Open Access 05 August 2023
-
Polycomb group-mediated histone H2A monoubiquitination in epigenome regulation and nuclear processes
Nature Communications Open Access 23 November 2020
-
BAP1/ASXL1 recruitment and activation for H2A deubiquitination
Nature Communications Open Access 07 January 2016
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Harbour, J.W. et al. Science 330, 1410–1413 (2010).
Bott, M. et al. Nat. Genet. 43, 668–672 (2011).
Wiesner, T. et al. Nat. Genet. 43, 1018–1021 (2011).
Testa, J.R. et al. Nat. Genet. 43, 1022–1025 (2011).
Forbes, S.A. et al. Curr. Protoc. Hum. Genet. 57, 10.11.1–10.18.27 (2008).
Forbes, S.A. et al. Nucleic Acids Res. 39, D945–D950 (2011).
Jensen, D.E. et al. Oncogene 16, 1097–1112 (1998).
Buchhagen, D.L., Qiu, L. & Etkind, P. Int. J. Cancer 57, 473–479 (1994).
Thiberville, L. et al. Int. J. Cancer 64, 371–377 (1995).
Wood, L.D. et al. Science 318, 1108–1113 (2007).
Ventii, K.H. et al. Cancer Res. 68, 6953–6962 (2008).
Machida, Y.J., Machida, Y., Vashisht, A.A., Wohlschlegel, J.A. & Dutta, A. J. Biol. Chem. 284, 34179–34188 (2009).
Matsuoka, S. et al. Science 316, 1160–1166 (2007).
Scheuermann, J.C. et al. Nature 465, 243–247 (2010).
Stokes, M.P. et al. Proc. Natl. Acad. Sci. USA 104, 19855–19860 (2007).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Goldstein, A. Germline BAP1 mutations and tumor susceptibility. Nat Genet 43, 925–926 (2011). https://doi.org/10.1038/ng.956
Published:
Issue Date:
DOI: https://doi.org/10.1038/ng.956
This article is cited by
-
Deficiency of BAP1 inhibits neuroblastoma tumorigenesis through destabilization of MYCN
Cell Death & Disease (2023)
-
H2A monoubiquitination: insights from human genetics and animal models
Human Genetics (2023)
-
Roles and mechanisms of BAP1 deubiquitinase in tumor suppression
Cell Death & Differentiation (2021)
-
Polycomb group-mediated histone H2A monoubiquitination in epigenome regulation and nuclear processes
Nature Communications (2020)
-
BAP1/ASXL1 recruitment and activation for H2A deubiquitination
Nature Communications (2016)