Complex autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, type 1 diabetes, multiple sclerosis, psoriasis and inflammatory bowel disease have different pathological presentations but have overlapping genetic susceptibility variants. A new study using mice lacking Tnfaip3, whose ortholog is linked to autoimmune disease in humans, leads to insights in the role of one molecular driver of varied clinical symptomatology in disparate autoimmune disorders.
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F.M. and V.M.D. are employees of Genentech, a member of the Roche group.
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Martin, F., Dixit, V. A20 edits ubiquitin and autoimmune paradigms. Nat Genet 43, 822–823 (2011). https://doi.org/10.1038/ng.916
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DOI: https://doi.org/10.1038/ng.916
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