Mapping higher order structure of chromatin domains

Large-scale mapping of chromatin state and transcription factor binding have uncovered many broad chromatin domains along linear genomic DNA, but it is unclear how these functional domains are organized in three-dimensional nuclear space. A new study now shows that many domains exist as loops connected by CCTC-binding factor (CTCF), providing new insights into the higher-order structure of chromatin organization in the nucleus.

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Figure 1: Five distinct chromatin domains are found in association with CTCF in mouse embryonic stem cells.

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Correspondence to Bing Ren.

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Espinoza, C., Ren, B. Mapping higher order structure of chromatin domains. Nat Genet 43, 615–616 (2011). https://doi.org/10.1038/ng.869

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