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SOX2 and CHD7 cooperatively regulate human disease genes

Nature Genetics volume 43, pages 505506 (2011) | Download Citation

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A new study reveals that the HMG-box transcription factor SOX2 coupled with the chromatin remodeling helicase CHD7 cooperatively regulate target genes that are essential during neural stem cell development. Notably, this complex controls the expression of several disease-associated genes, suggesting a possible mechanistic connection between five seemingly unrelated human genetic disorders.

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References

  1. 1.

    et al. Nat. Genet. 43, 607–611 (2011).

  2. 2.

    et al. Nature 346, 245–250 (1990).

  3. 3.

    et al. Nat. Neurosci. 10, 1181–1190 (2010).

  4. 4.

    et al. Genes Dev. 17, 126–140 (2003).

  5. 5.

    et al. Am. J. Med. Genet. A 138A, 95–98 (2005).

  6. 6.

    et al. Hum. Mol. Genet. 15, 1413–1422 (2006).

  7. 7.

    et al. J. Clin. Invest. 116, 2442–2455 (2006).

  8. 8.

    et al. Genome Res. 19, 590–601 (2009).

  9. 9.

    et al. PLoS Genet. 6, e1001023 (2010).

  10. 10.

    et al. Nature 463, 958–962 (2010).

  11. 11.

    et al. Nature Nat. Genet. 36, 955–957 (2004).

  12. 12.

    Ernst Schering Found. Workshop 61, 89–115 (2007).

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Author information

Affiliations

  1. Janusz Puc and Michael G. Rosenfeld are at the Howard Hughes Medical Institute, University of California, San Diego, La Jolla, California, USA.

    • Janusz Puc
    •  & Michael G Rosenfeld

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Michael G Rosenfeld.

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DOI

https://doi.org/10.1038/ng.843

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