Interferon-alfa, interferon-λ and hepatitis C

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Three new studies report genetic variants near IL28B, which encodes interferon-λ3 (interleukin 28B), are associated with response to treatment of chronic hepatitis C virus infection with interferon-alfa/ribavirin combination therapy. This renews interest in how interferons suppress viremia and could lead to improved clinical decisions for chronic HCV infection treatment based on individual genotype.

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Figure 1: The interferon-λ proteins induce the JAK-STAT antiviral pathway by binding to different receptors than interferon-α and interferon-alfa.

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Correspondence to Thomas R O'Brien.

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