News and Views

Genetic insights into mammalian heart regeneration

Genetic and functional analyses of 120 mouse strains have identified a heart regeneration candidate gene that modulates the contractile sarcomeric apparatus. This gene, Tnni3k, controls the frequency of the mononuclear, diploid cardiomyocyte population, which affects cardiomyocyte proliferative potential after injury.

  • Subscribe to Nature Genetics for full access:

    $59

    Subscribe

Additional access options:

Already a subscriber?  Log in  now or  Register  for online access.

References

  1. 1.

    et al. Science 331, 1078–1080 (2011).

  2. 2.

    et al. Proc. Natl. Acad. Sci. USA 110, 1446–1451 (2013).

  3. 3.

    et al. Nature 493, 433–436 (2013).

  4. 4.

    et al. Science 324, 98–102 (2009).

  5. 5.

    et al. Cell 161, 1566–1575 (2015).

  6. 6.

    et al. Nat. Genet. 49, 1346–1353 (2017).

  7. 7.

    et al. Sci. Transl. Med. 5, 207ra141 (2013).

  8. 8.

    et al. PLoS Genet. 5, e1000647 (2009).

  9. 9.

    , , , & Am. J. Physiol. 271, H2183–H2189 (1996).

  10. 10.

    et al. Dev. Growth Differ. 54, 731–738 (2012).

  11. 11.

    et al. Circulation (2017).

  12. 12.

    , & Physiol. Rev. 87, 521–544 (2007).

  13. 13.

    & Genomics 89, 70–80 (2007).

  14. 14.

    & Circ. Res. 121, 293–309 (2017).

  15. 15.

    et al. Hum. Mol. Genet. 23, 5793–5804 (2014).

Download references

Author information

Affiliations

  1. Ana Vujic, Vinícius Bassaneze and Richard T. Lee are at the Department of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA.

    • Ana Vujic
    • , Vinícius Bassaneze
    •  & Richard T Lee

Authors

  1. Search for Ana Vujic in:

  2. Search for Vinícius Bassaneze in:

  3. Search for Richard T Lee in:

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Richard T Lee.