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Monogenic immune disorders and severe atopic disease

Nature Genetics volume 49, pages 11621163 (2017) | Download Citation

Severe allergic disease is common, and few monogenic causes of atopy have been described. A new study that convincingly links severe atopic dermatitis to heterozygous CARD11 mutations with dominant-interfering activity serves as a timely reminder that clinicians should consider the possibility of an underlying monogenic immune disorder when caring for patients suffering from severe allergic disease.

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Author information

Affiliations

  1. Catherine M. Biggs, Henry Y. Lu and Stuart E. Turvey are in the Department of Pediatrics, British Columbia Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.

    • Catherine M Biggs
    • , Henry Y Lu
    •  & Stuart E Turvey
  2. Catherine M. Biggs and Henry Y. Lu are also in the Department of Experimental Medicine, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

    • Catherine M Biggs
    •  & Henry Y Lu

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Stuart E Turvey.

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DOI

https://doi.org/10.1038/ng.3925

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