Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Promoting transcription over long distances

Promoters and enhancers have long been regarded as distinct elements, a notion that has been challenged more recently. Two new studies now identify promoters that function as long-range enhancers in vivo to regulate the transcription of distal genes.

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Promoters regulate distal gene transcription.

References

  1. Kim, T.-K. & Shiekhattar, R. Cell 162, 948–959 (2015).

    CAS  Article  Google Scholar 

  2. Core, L.J. et al. Nat. Genet. 46, 1311–1320 (2014).

    CAS  Article  Google Scholar 

  3. Kowalczyk, M.S. et al. Mol. Cell 45, 447–458 (2012).

    CAS  Article  Google Scholar 

  4. Zabidi, M.A. et al. Nature 518, 556–559 (2015).

    CAS  Article  Google Scholar 

  5. Arnold, C.D. et al. Science 339, 1074–1077 (2013).

    CAS  Article  Google Scholar 

  6. Li, G. et al. Cell 148, 84–98 (2012).

    CAS  Article  Google Scholar 

  7. Diao, Y. et al. Nat. Methods 14, 629–635 (2017).

    CAS  Article  Google Scholar 

  8. Dao, L.T.M. et al. Nat. Genet. 49, 1073–1081 (2017).

    CAS  Article  Google Scholar 

  9. Rajagopal, N. et al. Nat. Biotechnol. 34, 167–174 (2016).

    CAS  Article  Google Scholar 

  10. Engreitz, J.M. et al. Nature 539, 452–455 (2016).

    CAS  Article  Google Scholar 

  11. Paralkar, V.R. et al. Mol. Cell 62, 104–110 (2016).

    CAS  Article  Google Scholar 

  12. Corrales-Berjano, M. et al. Genome Res. http://dx.doi.org/10.1101/gr.211433.116 (2017).

  13. Birnbaum, R.Y. et al. Genome Res. 22, 1059–1068 (2012).

    CAS  Article  Google Scholar 

  14. Andersson, R. et al. Nature 507, 455–461 (2014).

    CAS  Article  Google Scholar 

  15. Arnold, C.D. et al. Nat. Biotechnol. 35, 136–144 (2017).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Alexander Stark.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Catarino, R., Neumayr, C. & Stark, A. Promoting transcription over long distances. Nat Genet 49, 972–973 (2017). https://doi.org/10.1038/ng.3904

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng.3904

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing